Research
E²LSI

E²LSI Group

This interdisciplinary research group focuses on epistemic, ethical, legal and social issues (E2LSI) of research in the life sciences with a strong focus on animal-related research. It primarily addresses questions where ethical/regulatory and epistemic aspects are intertwined, e.g. in the contexts of chimera and xenotransplantation research, animal experimentation in biomedicine and the validation of alternatives to animal experimentation.

This interdisciplinary research group focuses on epistemic, ethical, legal and social issues (E2LSI) of research in the life sciences with a strong focus on animal-related research. It primarily addresses questions where ethical/regulatory and epistemic aspects are intertwined, e.g. in the contexts of chimera and xenotransplantation research, animal experimentation in biomedicine and the validation of alternatives to animal experimentation.

The research group aims at integrating theoretical and practical elements in two respects: first, by combining insights and methods from philosophy of science, and science studies (including socio-legal studies) with normative bioethics, and second, by paying detailed attention to actual life science practices against the backdrop of theoretical discourse in philosophy, law and social science. The group is currently involved in these third party funded projects:

CURRENT E2LSI PROJECTS

Photo by Drew Hays Photo by Drew Hays Photo by Drew Hays © Photo von Drew Hays
Barriers for alternative methods to animal experimentation

Simon Lohse (in cooperation with Lisa Hermann, Nils Hoppe & Rebecca Knab)

 

This research project analyses epistemic barriers for the development and acceptance of alternative methods to animal experimentation in basic and applied research. It attempts to integrate a socio-epistemological perspective with recent insights from the philosophy of the life sciences to explore the status quo of the animal experimentation regime and to draw out normative implications for the (self-)regulation of science. This project is conducted within the scientific network "R2N - Reduce and Replace in Lower Saxony".

 

Barriers for alternative methods to animal experimentation

Simon Lohse (in cooperation with Lisa Hermann, Nils Hoppe & Rebecca Knab)

 

This research project analyses epistemic barriers for the development and acceptance of alternative methods to animal experimentation in basic and applied research. It attempts to integrate a socio-epistemological perspective with recent insights from the philosophy of the life sciences to explore the status quo of the animal experimentation regime and to draw out normative implications for the (self-)regulation of science. This project is conducted within the scientific network "R2N - Reduce and Replace in Lower Saxony".

 

Image by: Finlayson, K., et al. (2016). Facial indicators of positive emotions in rats. PLoS One, 11(11), e0166446. Image by: Finlayson, K., et al. (2016). Facial indicators of positive emotions in rats. PLoS One, 11(11), e0166446. Image by: Finlayson, K., et al. (2016). Facial indicators of positive emotions in rats. PLoS One, 11(11), e0166446. © Kathryn Finlayson
Ethical and legal aspects of severity assessment in animal experimentation

Rebecca Knab & Nils Hoppe (in cooperation with Simon Lohse)

 

This project investigates underlying concepts and philosophical assumptions of severity assessment in animal-based research. It aims to identify conceptual, epistemological and methodological issues of scientific practice and regulation through the integration of empirical research and philosophical analysis. The generated knowledge will establish a basis for the ethical assessment of the status quo and for science- and policy-directed recommendations that will support scientists in addressing practical issues of severity assessment and improve regulation. The project is conducted in close cooperate with the DFG research group “Severity assessment in animal-based research”.

Ethical and legal aspects of severity assessment in animal experimentation

Rebecca Knab & Nils Hoppe (in cooperation with Simon Lohse)

 

This project investigates underlying concepts and philosophical assumptions of severity assessment in animal-based research. It aims to identify conceptual, epistemological and methodological issues of scientific practice and regulation through the integration of empirical research and philosophical analysis. The generated knowledge will establish a basis for the ethical assessment of the status quo and for science- and policy-directed recommendations that will support scientists in addressing practical issues of severity assessment and improve regulation. The project is conducted in close cooperate with the DFG research group “Severity assessment in animal-based research”.

Ethical aspects regarding stem cell research and the creation of chimeras

Koko Kwisda (in cooperation with Tobias Cantz, Nils Hoppe, Dietmar Hübner and Lucie White)

 

This PhD project is concerned with human-animal chimera research and the bioethical debate surrounding it. The research focuses on the philosophical analysis and systematisation of arguments related to chimera research (e.g. metaphysical and ethical arguments). The first part of this project consists in an empirical systematic review of the arguments. The second part analyses implications of current research and its surrounding discussion and regulation for the governance of chimera-based research (such as xenotransplantation).

Ethical aspects regarding stem cell research and the creation of chimeras

Koko Kwisda (in cooperation with Tobias Cantz, Nils Hoppe, Dietmar Hübner and Lucie White)

 

This PhD project is concerned with human-animal chimera research and the bioethical debate surrounding it. The research focuses on the philosophical analysis and systematisation of arguments related to chimera research (e.g. metaphysical and ethical arguments). The first part of this project consists in an empirical systematic review of the arguments. The second part analyses implications of current research and its surrounding discussion and regulation for the governance of chimera-based research (such as xenotransplantation).

Legal and ethical aspects of genome editing in agriculture

Martin Wasmer (in cooperation with Jürgen Robienski, Thomas Reydon and Nils Hoppe)

 

As part of the project ELSA-GEA (see “Current Research Projects”), biological terms (e.g. GMO, mutagenesis, gene, species boundary, etc.) and philosophical assumptions underlying German and European genetic engineering law are investigated. The definition of such terms is legally relevant, but their meaning is derived in different ways from scientific practice. Thus, the project integrates legal aspects and aspects from philosophy of science to clarify epistemological and ontological questions in the context of biotechnology regulation. The insights gained will contribute to a productive discussion among the interested public and decision-makers and will help to identify options for regulatory or legislative measures.

Legal and ethical aspects of genome editing in agriculture

Martin Wasmer (in cooperation with Jürgen Robienski, Thomas Reydon and Nils Hoppe)

 

As part of the project ELSA-GEA (see “Current Research Projects”), biological terms (e.g. GMO, mutagenesis, gene, species boundary, etc.) and philosophical assumptions underlying German and European genetic engineering law are investigated. The definition of such terms is legally relevant, but their meaning is derived in different ways from scientific practice. Thus, the project integrates legal aspects and aspects from philosophy of science to clarify epistemological and ontological questions in the context of biotechnology regulation. The insights gained will contribute to a productive discussion among the interested public and decision-makers and will help to identify options for regulatory or legislative measures.

GROUP MEMBERS


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